Answers to complex questions cannot be derived from "simple" trials

Answers to complex questions cannot be derived from " simple " trials

As we progress in the exciting area of treatment of acute myocardial infarction, two clinical trial methodologies coming from different philosophies and traditions must be considered. Smaller (200-3000 patient), detailed trials focusing on pathophysiology will be referred to as "mini-trials", while mammoth studies (10 000-50 000 patients) designed to measure mortality rates will be referred to ...

Answers to complex questions cannot be derived from 'simple' trials.

As we progress in the exciting area of treatment of acute myocardial infarction, two clinical trial methodologies coming from different philosophies and traditions must be considered. Smaller (200-3000 patient), detailed trials focusing on pathophysiology will be referred to as "mini-trials", while mammoth studies (10 000-50 000 patients) designed to measure mortality rates will be referred to ...

Complex Questions Rarely Have Simple Answers.

The subject of this monograph—sex differences in science and mathematics—is controversial. Although a topic of discussion for years, this issue was brought to public attention again in 2005 by the much-quoted comments of Lawrence Summers, then president of Harvard University, suggesting that at least part of the reason for the dearth of women at the top in math and science professions is a lack...

Finding Answers to Complex Questions

Thyroid hormone replacement therapy: three 'simple' questions, complex answers.

Current guidelines recommend that hypothyroid patients should be treated with levothyroxine, which in the vast majority of the cases leads to resolution of the symptoms and normalization of serum free T4 (FT4), T3 and TSH levels. However, a small group of hypothyroid patients remain symptomatic for neurocognitive dysfunction despite normal serum FT4 and TSH, which could be explained by localize...